The next year, Daniels starred in two films (Love Hurts and The Butcher's Wife).
He has received a number of award nominations for his work on stage, including Tony Award nominations for Best Actor for his roles in the plays God of Carnage and Blackbird.He attended Central Michigan University and participated in the school's theater program.In the summer of 1976, Daniels attended the Eastern Michigan University drama school to participate in a special Bicentennial Repertory program, where he performed in The Hot l Baltimore and three other plays performed in repertoire. Mason was the guest director at EMU and he invited Jeff to come to New York to work at the Circle Repertory Theatre, where he performed in Fifth of July by Lanford Wilson in the 1977–78 season.Daniels reprised the role of Chamberlain ten years later in the prequel film Gods and Generals.
In 1994, Daniels would co-star with Jim Carrey in one of his most commercially successful films, Dumb and Dumber.
He is the founder and current executive director of the Chelsea, Michigan-based Purple Rose Theatre Company.